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DescriptionSeborrheic dermatitis and hair loss In order to achieve optimum efficacy and tolerability, fumaric acid esters should be dosed in a gradual manner. In the first week a tablet of the initial form is taken in the evening, in the second week one tablet each morning and evening, in the third week three times a tablet daily. From the fourth week, Fumaderm is taken, in the fourth week a tablet in the evening, in the fifth week a tablet in the morning and in the evening and in the sixth week three times a tablet daily. In the following weeks the daily dose can be increased weekly by one tablet to a maximum of three times two tablets. However, this maximum dose is only necessary in isolated cases. After the skin has elapsed (after the fourth to sixth week), the dosage should gradually be reduced to the individually required maintenance dose. It is between one and six tablets daily.

application Notes

The gastric juice-resistant tablets are undecorated and taken with plenty of liquid during or immediately after the meal. The patient should be able to absorb sufficient fluid - about one and a half to two liters - during the day.

compatibility

Animal experiments on acute toxicity revealed that the combination of fumaric acid esters is less toxic than the single substances. In animal studies on chronic toxicity, leukocytosis, lymphopenia, seborrheic dermatitis and hair loss hepatic weight, gastric impairment and dose-dependent renal toxicity were observed. Since gastric damage is presumably a consequence of the acidity of the active ingredients, it can be largely excluded in gastric juice-resistant tablets.

From clinical trials, the most common side effects are flush symptoms with facial redness and heat sensation as well as gastrointestinal discomfort. In the gastrointestinal complaints dominate diarrhea, but also upper abdomen cramps, voluptuousness, flatulence and nausea occur. Rarely, fatigue, dizziness, and headache were observed. The side effects frequently recur with a progressive treatment period. A dose reduction generally reduces them considerably [6]. Nephrotoxicity can only be expected in isolated cases.

In a 16-week double blind study with 100 patients, 75% of patients treated with the antipsorial drug and 16% of placebo-treated side effects occurred seborrheic keratosis treatment. The most common cases were abdominal pain / abdominal cramps (35 episodes) followed by diarrhea and flush. In an open 12-month study with 83 patients, 62% of patients had side effects: 52% suffered from flush, 32% from diarrhea, and 15% from abdominal pain. Symptoms were reversible with continued treatment.
Created11 Oct 2017
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CountryUnited States
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