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Message boards : Science : Gibbs sampler

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Robert H
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Message 4802 - Posted: 7 Nov 2014, 12:21:37 UTC

What is Gibbs sampler? I know from past that some genes are on and som are off but i need deeper understanding of how it works.

Travis Desell
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Message 4804 - Posted: 8 Nov 2014, 21:49:06 UTC - in response to Message 4802.
Last modified: 14 Jan 2015, 15:02:18 UTC

What is Gibbs sampler? I know from past that some genes are on and som are off but i need deeper understanding of how it works.


Hi Robert,

Gibbs Sampling is a markov chain monte carlo style sampling algorithm. Basically what our gibbs sampler is doing is making probabilistic sampling walks in the DNA sequences we send out, looking for areas that the DNA sequences have in common. As DNA is kind of messy, we can't look for exact matches, and Gibbs sampling gives us a way to find semi-matched areas across all the samples. At the end of the sampling walks, the areas that were sampled the most have the highest potential to be protein binding sites.

Hope that helps and let me know if you have any other questions!

--Travis


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Message boards : Science : Gibbs sampler